If you’ve ever used or thought about using Kratom, one question might have popped into your head: “Is Kratom like opioids?”.
It makes sense to ask this question since there’s more and more data coming out about how there are similarities to opioids, as well as side effects and withdrawal symptoms.
Here’s a little spoiler: The answer to our question becomes rather concerning when we’re talking about synthetic Kratom isolates.
What Are Synthetic Kratom Isolates and Why Are They Riskier?
Traditional Kratom (made from the leaves of the Mitragyna speciosa tree) contains 20–40 natural alkaloids. Each one of them has potentially different effects.
In Southeast Asia, it’s been used for centuries as a mild stimulant for workers in the fields, or as a natural pain reliever brewed into tea. This whole-plant form is complex: its multiple compounds often “balance” each other out. That makes the effects more gradual and predictable.
But in recent years, a new, riskier form has appeared: lab-made, high potency Kratom isolates.
These products strip away that natural balance. Instead, they only focus on one or two of the most potent alkaloids (usually mitragynine or 7-hydroxymitragynine).
In nature, 7-hydroxy is barely present in the leaf. But when it’s produced in a lab and sold as a stand-alone ingredient, it acts almost identically to pharmaceutical opioids.
That means the answer to the question “Is Kratom like opioids?” changes from “sometimes” to “almost always” when it comes to isolates. With these concentrated forms, the risk of dependence, dangerous side effects, and even overdose skyrockets.
Many of these synthetics forms of Kratom are sold without quality control, dosing guidelines, or clear labeling. That makes it even worse.
Whole-Plant vs. Isolate
In the natural leaf, the 20–40 alkaloids can balance each other’s effects. Isolating just one can lead to stronger, less predictable (and more dangerous) results. Think of it like the difference between chewing coca leaves and snorting cocaine, or sipping coffee versus taking high doses of pure caffeine powder.
That also means that the natural “safety buffers” are lost with modern synthetic Kratom. Historically, people harvested, prepared, and consumed whole plants. They got feedback from taste, smell, and ritual. With modern isolates, you bypass all that and go straight to a highly concentrated dose. That increases the risk of taking too much, too fast.
Some synthetic products aren’t even Kratom-derived. They’re chemically engineered to mimic Kratom’s effects. What that means is our bodies have no evolutionary familiarity with them. This can make their side effects unpredictable. When combined with other substances like alcohol or sedatives, it can end in even more dangerous side effects.
Is Kratom Like Opioids? How Synthetic Isolates Affect the Brain
One of the main reasons high potency Kratom isolates are so risky is that they target the same mu-opioid receptors in the brain that drugs like heroin, oxycodone, and fentanyl do. These receptors regulate pain, pleasure, sedation…and even breathing.
- In low doses, you might feel mild pain relief, focus, or mood elevation.
- In higher doses, the effects can resemble a full opioid high, along with Kratom overdose signs such as slow or shallow breathing, extreme drowsiness, confusion, and even unconsciousness.
Because isolates are so concentrated, tolerance builds much faster than with natural Kratom tea or powder. A small dose today may have little effect a week later. That can push you to take more. This escalates the risk of dependence and Kratom withdrawal symptoms (which can include anxiety, muscle aches, insomnia, nausea, and intense cravings).
These isolates, despite being legal in some areas, are chemically closer to opioids than to traditional Kratom. This makes the dangers of Kratom use much more severe.
Why People Turn to Synthetic Kratom Isolates
Many people begin using synthetic Kratom isolates because they believe they’ve found a “natural” and therefore safer alternative to opioids. The marketing often paints these products as herbal remedies…something you can buy at a vape shop, online store, or even a café without a prescription.
Some are trying to manage opioid withdrawal without medical supervision. They’re hoping that Kratom will take the edge off symptoms like body aches, anxiety, insomnia, and low mood.
Others are looking for a “legal high”, for something that delivers the relaxation or euphoria of prescription painkillers or heroin, but without the stigma or legal risk.
The 3 Hidden Dangers of High Potency Kratom
The dangers of Kratom use increase dramatically when we’re talking about synthetic isolates rather than whole-plant powder or tea.
The problem is that when you ask “Is Kratom like opioids?”, the answer moves much closer to “yes” with these high potency Kratom products.
1. Overdose potential
Because these products are so concentrated, it’s incredibly easy to take too much, even for experienced Kratom users. Kratom overdose signs can include:
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- Slow or shallow breathing
- Extreme drowsiness or inability to stay awake
- Confusion or disorientation
- Loss of consciousness
According to the FDA, 7-hydroxymitragynine isolates even come with a risk of respiratory depression that is similar to what we see with opioids. It can be life-threatening without immediate medical intervention.
2. Severe withdrawal symptoms
The more potent the Kratom, the more Kratom withdrawal symptoms you may face when quitting. These can include intense muscle aches, anxiety, irritability, nausea, insomnia, and powerful cravings. For some, the withdrawal can feel as bad (or worse) than what they were originally trying to escape.
3. No quality control
Most synthetic Kratom isolates are unregulated. There’s no standardized dosing, no safety testing, and no reliable labeling. One batch might be relatively mild while the next could be dangerously potent. It’s very unpredictable and that is a major factor in accidental overdoses.
Why Kratom Home Detox Is The Safest Kratom Detox Treatment
If you’re struggling with opioid use or dependence on high potency Kratom, the safest path forward is medically supervised in home detox.
No, not DIY attempts with unregulated, unpredictable products. We’re talking about professionally supervised medical detox at home.
Here’s why in home Kratom detox is safer:
- Professional oversight: Our experienced medical team can monitor your symptoms and adjust care in real time.
- Personalized plan: Detox is personalized to your health history and usage patterns.
- Comfort & privacy: You recover in your own home, and avoid the stress and drama of an inpatient rehab setting.
- Lower relapse risk: Having medical professionals guide you through withdrawal reduces the urge to reach for Kratom or opioids to “take the edge off.”
With Kratom detox treatment at home, you’re setting yourself up for long-term recovery in a safe, familiar environment.
Get Help for High Potency Kratom Addiction
Trying to self-detox with synthetic Kratom isolates is risky and often leads to more problems than it solves. These products can be just as addictive and dangerous as the substances they’re meant to replace.
At Detox Concierge, we don’t just offer at home Kratom detox. We can also assist you with at home alcohol detox, at home opioid detox and at home cocaine detox. We’re based in Newport Beach in Orange County, but we serve clients across the US, no matter what state or city.
Our in home detox services can give you privacy, comfort, and peace of mind. If you’re ready to get help for your Kratom addiction, reach out to us today for a free consultation.